//M0//QN1//CS//DL0//EQ
The disease is controlled by a single pair of allele, HbA and HbS. Out of the three possible genotypes only homozygous individuals for HbS (HbS HbS) show the diseased phenotype. Heterozygous (HbA HbS) individuals appear apparently unaffected but they are carrier of the disease as there is 50 per cent probability of transmission of the mutant gene to the progeny.
(i) What happens due to mutation in the HbA gene in sickle cell anaemia?(ii) Which type of mutation seen in the sickle cell anaemia?(iii) What happens due to substitution of GAG with GUG?(iv) What amino acids are present at the fifth and seventh position of HbA peptide?
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(no answer)